Structure of PDB 6cav Chain C

Receptor sequence
>6cavC (length=285) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
VKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFYAKEKA
IYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSE
EEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYND
LTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGII
DFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQD
IVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTY
3D structure
PDB6cav Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia.
ChainC
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP C I224 K226 Y237 Y274 E276 I277 F281 H379 I392 D393 I39 K41 Y45 Y82 E84 I85 F89 H187 I200 D201
BS02 MG C H379 D393 H187 D201
BS03 84D C D374 S376 D396 Y408 E411 E415 E416 E445 Y448 E451 D182 S184 D204 Y216 E219 E223 E224 E253 Y256 E259
External links
PDB RCSB:6cav, PDBe:6cav, PDBj:6cav
PDBsum6cav
PubMed29661878
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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