Structure of PDB 6cas Chain C

Receptor sequence

>6casC (length=206) Species: 300852 (Thermus thermophilus HB8)

GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAG
LARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVAL
NVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKV
IVSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAY
IFLGEV

3D structure

• PDB: 6cas Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature.
• Chain: C
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	C	G2 N3 K4 I5 K26 K27 R127 S154 G155 R156 G159 E161 Q162 A163 W167 G171 R172 V173 P174 L175 H176 T177 L178 R179 T192 Y193 V195 K199	G1 N2 K3 I4 K25 K26 R126 S153 G154 R155 G158 E160 Q161 A162 W166 G170 R171 V172 P173 L174 H175 T176 L177 R178 T191 Y192 V194 K198
BS02	MG	C	A129 V130	A128 V129
BS03	MG	C	R11 R179 A180 I182	R10 R178 A179 I181

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6cas, PDBe:6cas, PDBj:6cas
• PDBsum: 6cas
• PubMed: 30113694
• UniProt: P80372|RS3_THET8 Small ribosomal subunit protein uS3 (Gene Name=rpsC)