Structure of PDB 6c91 Chain C

Receptor sequence
>6c91C (length=214) Species: 9615 (Canis lupus familiaris) [Search protein sequence]
EKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDE
NALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSQ
STSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADP
RGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKT
GGGGKTVWDWELMN
3D structure
PDB6c91 Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
ChainC
Resolution2.895 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EQD C N107 D149 M154 N162 F195 I247 N34 D76 M81 N89 F109 I161 PDBbind-CN: -logKd/Ki=6.19,Kd=0.65uM
BindingDB: Ki=440nM,IC50=1200nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6c91, PDBe:6c91, PDBj:6c91
PDBsum6c91
PubMed29528635
UniProtP41148|ENPL_CANLF Endoplasmin (Gene Name=HSP90B1)

[Back to BioLiP]