Structure of PDB 6c89 Chain C

Receptor sequence

>6c89C (length=228) Species: 562 (Escherichia coli) [Search protein sequence]

DQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTA
WTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYAN
ALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSD
NITVGIDGTDIAFGGCLIRDSKAKSLAQLGDADTEHYAASARAFGAAFPK
ASMIVMSHSAPDSRAAITHTARMADKLR

3D structure

PDB

6c89 Differential active site requirements for NDM-1 beta-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics.

Chain

Resolution

1.75006 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H116 H118 D120 H196 C221 R224 Q233 H263
Catalytic site (residue number reindexed from 1)	H78 H80 D82 H147 C166 R169 Q178 H208
Enzyme Commision number	3.5.2.6: beta-lactamase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	C	D120 C221 H263	D82 C166 H208
BS02	ZN	C	H116 H118 H196	H78 H80 H147

External links

PDB	RCSB:6c89, PDBe:6c89, PDBj:6c89
PDBsum	6c89
PubMed	30375382
UniProt	E5KIY2

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