Structure of PDB 6c7f Chain C

Receptor sequence
>6c7fC (length=319) Species: 9606 (Homo sapiens) [Search protein sequence]
IQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTL
ARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFAL
FISCMCHDLDHRGTNNSFQVLYSSEGSVMERHHFAQAIAILNTHGCNIFD
HFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHR
LLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEM
MDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTK
VSHKFTIRGLPSNNSLDFL
3D structure
PDB6c7f Mathematical and Structural Characterization of Strong Nonadditive Structure-Activity Relationship Caused by Protein Conformational Changes.
ChainC
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EOS C T768 L770 T805 I826 F830 F862 T171 L173 T208 I229 F233 F265 MOAD: ic50=0.00000001M
BS02 ZN C H660 H696 D697 D808 H71 H107 D108 D211
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6c7f, PDBe:6c7f, PDBj:6c7f
PDBsum6c7f
PubMed30070482
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

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