Structure of PDB 6c5u Chain C

Receptor sequence
>6c5uC (length=287) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
VKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTKFYAKEKA
IYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIYSTMSE
EEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYND
LTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNRLTGII
DFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKAKEYQD
IVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD
3D structure
PDB6c5u Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia.
ChainC
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP C I224 K226 Y237 Y274 I277 F281 H379 I392 D393 I39 K41 Y45 Y82 I85 F89 H187 I200 D201
BS02 MG C H379 D393 H187 D201
External links
PDB RCSB:6c5u, PDBe:6c5u, PDBj:6c5u
PDBsum6c5u
PubMed29661878
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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