Structure of PDB 6bw8 Chain C

Receptor sequence
>6bw8C (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGAKKPMGRATSRKALETLRRVGDGVQRNHE
TAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVA
HLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
3D structure
PDB6bw8 Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design.
ChainC
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ECM C H224 A227 F228 M231 L246 V253 F254 N260 R263 T266 L267 F270 G271 H49 A52 F53 M56 L71 V78 F79 N85 R88 T91 L92 F95 G96 BindingDB: Ki=<1.000000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6bw8, PDBe:6bw8, PDBj:6bw8
PDBsum6bw8
PubMed29323899
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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