Structure of PDB 6bw6 Chain C

Receptor sequence
>6bw6C (length=365) Species: 9606 (Homo sapiens) [Search protein sequence]
PMPLLINLIVSLLGFVATVTLIPAFRGHFIAARLCGQDLNKTSRQQIPES
QGVISGAVFLIILFCFIPFPFLNCAFPHHEFVALIGALLAICCMIFLGFA
DDVLNLRWRHKLLLHTAASLPLLMVYFTNFGNTTIVHLDLGILYYVYMGL
LAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDCRDDHVFSL
YFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVVGILGHFSKTM
LLFFMPQVFNFLYSLPQLLHIIPCPRHRIPRLNIKTGKLEMSYSKFKTKS
LSFLGTFILKVAESLQLVTVHQCNNMTLINLLLKVLGPIHERNLTLLLLL
LQILGSAITFSIRYQ
3D structure
PDB6bw6 GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.
ChainC
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.8.15: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TUM C D45 W122 N185 I186 A188 G189 I190 N191 F249 D252 R303 I304 D38 W108 N160 I161 A163 G164 I165 N166 F224 D227 R278 I279
BS02 PGW C C107 F110 A114 H124 L127 C93 F96 A100 H110 L113
BS03 PGW C L28 A31 F32 H35 I68 F71 L21 A24 F25 H28 I61 F64
Gene Ontology
Molecular Function
GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006047 UDP-N-acetylglucosamine metabolic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0019348 dolichol metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bw6, PDBe:6bw6, PDBj:6bw6
PDBsum6bw6
PubMed29459785
UniProtQ9H3H5|GPT_HUMAN UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (Gene Name=DPAGT1)

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