Structure of PDB 6bw4 Chain C

Receptor sequence

>6bw4C (length=370) Species: 9606 (Homo sapiens) [Search protein sequence]

DDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEG
KDFSIHRLVLGTHTSDEQNHLVIASVQLPNGKIEIEIKINHEGEVNRARY
MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG
LSWNPNLSGHLLSASDDHTICLWDISAGKVVDAKTIFTGHTAVVEDVSWH
LLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE
FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS
GTDRRLNVWDLSKIGEEQSEDGPPELLFIHGGHTAKISDFSWNPNEPWVI
CSVSEDNIMQVWQMAENIYN

3D structure

PDB

6bw4 Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	E41 W42 P43 H71 S73 E126 N128 Y181 E231 D248 F321 E395 N397	E33 W34 P35 H63 S65 E94 N96 Y149 E195 D212 F285 E355 N357

Gene Ontology

	Molecular Function
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0005515	protein binding
GO:0008094	ATP-dependent activity, acting on DNA
GO:0031492	nucleosomal DNA binding
GO:0042393	histone binding
GO:0042826	histone deacetylase binding

	Biological Process
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0006260	DNA replication
GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0006335	DNA replication-dependent chromatin assembly
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0007420	brain development
GO:0008285	negative regulation of cell population proliferation
GO:0030336	negative regulation of cell migration
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0042659	regulation of cell fate specification
GO:0045892	negative regulation of DNA-templated transcription
GO:0045893	positive regulation of DNA-templated transcription
GO:1902455	negative regulation of stem cell population maintenance
GO:1902459	positive regulation of stem cell population maintenance
GO:2000736	regulation of stem cell differentiation

	Cellular Component
GO:0000118	histone deacetylase complex
GO:0000781	chromosome, telomeric region
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005829	cytosol
GO:0016581	NuRD complex
GO:0016589	NURF complex
GO:0032991	protein-containing complex
GO:0033186	CAF-1 complex
GO:0035098	ESC/E(Z) complex
GO:0070822	Sin3-type complex
GO:1904949	ATPase complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:6bw4, PDBe:6bw4, PDBj:6bw4
PDBsum	6bw4
PubMed	30462309
UniProt	Q09028\|RBBP4_HUMAN Histone-binding protein RBBP4 (Gene Name=RBBP4)

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