Structure of PDB 6bu0 Chain C

Receptor sequence
>6bu0C (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
NAIGGAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHK
TSKRKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRGNF
FLGGVTLPLKDFNLSKETVKWYQLTAAT
3D structure
PDB6bu0 Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2 alpha.
ChainC
Resolution2.427 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP C Y1595 K1597 Y1599 K1606 K1609 K1611 Y39 K41 Y43 K50 K53 K55
BS02 IHP C K1564 W1677 K8 W121
External links
PDB RCSB:6bu0, PDBe:6bu0, PDBj:6bu0
PDBsum6bu0
PubMed30293811
UniProtO00443|P3C2A_HUMAN Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Gene Name=PIK3C2A)

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