Structure of PDB 6brd Chain C

Receptor sequence
>6brdC (length=468) Species: 953739 (Streptomyces venezuelae ATCC 10712) [Search protein sequence]
MFDVIVVGGGPTGLMLAGELRLHGVRVLVLEKETEPTRQSRAQGLHVRSI
EVMAQRGLLERFLERGHTVAVGGFFAGLATSWPERLDTAHSYVLAVPQVI
TEQLLAEHATALGAEIRRGRALVGLRQDEDGVTVDLADGEQLRARYVVGC
DGGRSTVRKLLGVAFPGEPSRVETLLGEMASQEELTSVMTEVRKTQQRFG
AMPGVFRVVVPAEGVAEDRTASPTLDEFKQQLRAHAGTDFGVHSPRWLSR
FGDATRQAERYRVDRVFLAGDAAHIHPPTGGQGLNLGIQDAFNLGWKLAA
EVDGWAPEGLLDTYHAERHPVATEVLDNTRAQIQLMSTEPGPQAVRRLMA
ELVEFENVNRYLIEKITAISVRYDVGEGHELLGRRMRDLALKHGRLYERM
HEGRGLLLDQTGRLSVAGWEDRVDHVVEVSEELDVPAVLLRPDGHVVWAG
EDQQELLTRMPAWFGAAT
3D structure
PDB6brd Rox, a Rifamycin Resistance Enzyme with an Unprecedented Mechanism of Action.
ChainC
Resolution3.32 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q43 V215 P284 Q288 H431
Catalytic site (residue number reindexed from 1) Q43 V209 P278 Q282 H425
Enzyme Commision number 1.14.13.211: rifampicin monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C V7 G10 T12 L30 E31 K32 R41 A42 Q98 L122 D151 G152 T156 D277 P284 G287 L290 V7 G10 T12 L30 E31 K32 R41 A42 Q98 L122 D151 G152 T156 D271 P278 G281 L284
BS02 RFP C Q43 F74 R196 G203 M205 R213 P284 T285 G286 Q43 F74 R193 G200 M202 R207 P278 T279 G280
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004497 monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0071949 FAD binding

View graph for
Molecular Function
External links
PDB RCSB:6brd, PDBe:6brd, PDBj:6brd
PDBsum6brd
PubMed29398560
UniProtF2R776|ROX_STRVP Rifampicin monooxygenase (Gene Name=rox)

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