Structure of PDB 6bo7 Chain C

Receptor sequence
>6bo7C (length=219) Species: 5855 (Plasmodium vivax) [Search protein sequence]
HKIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNGVL
KNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSSTE
SPKHLYVEHYVRVKSIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCEY
LKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEKF
RDLDHLCLVNDEGIKKFRT
3D structure
PDB6bo7 Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ChainC
Resolution2.856 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) E144 D145 D148 F197 R210
Catalytic site (residue number reindexed from 1) E135 D136 D139 F188 R201
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C E144 D145 E135 D136
BS02 YPG C K77 R112 I146 D148 T149 G150 T152 K176 F197 V198 D204 R210 K77 R112 I137 D139 T140 G141 T143 K167 F188 V189 D195 R201
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6bo7, PDBe:6bo7, PDBj:6bo7
PDBsum6bo7
PubMed29161011
UniProtA5K7E9

[Back to BioLiP]