Structure of PDB 6bjd Chain C

Receptor sequence
>6bjdC (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
EKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFQFVWKRPPEICENP
RFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENY
AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAY
AKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERG
SLMGCSIDDGYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWG
QVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKL
EICNLT
3D structure
PDB6bjd Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation.
ChainC
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q123 C129 H334 N358 W360
Catalytic site (residue number reindexed from 1) Q64 C70 H223 N247 W249
Enzyme Commision number 3.4.22.54: calpain-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E64 C W365 G367 W254 G256
BS02 CA C I113 D114 G115 N117 D120 E199 I54 D55 G56 N58 D61 E140
BS03 CA C E364 D371 T392 D394 E396 E253 D260 T281 D283 E285
BS04 E64 C Q123 G127 C129 G221 G222 S265 G333 H334 Q64 G68 C70 G162 G163 S206 G222 H223
Gene Ontology
Molecular Function
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bjd, PDBe:6bjd, PDBj:6bjd
PDBsum6bjd
PubMed29382717
UniProtP20807|CAN3_HUMAN Calpain-3 (Gene Name=CAPN3)

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