Structure of PDB 6be6 Chain C

Receptor sequence
>6be6C (length=433) Species: 9606 (Homo sapiens) [Search protein sequence]
AEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIR
QISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAY
VFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQ
NYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYI
MYARATSGDKLNNNKFSLCSIRQISQVLEKKRNNCFVESGQPICGNGMVE
QGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCA
FKSKSEKCRDDSDCAREGICNGFTALCPASDPKPQFTDCNRHTQVCINGQ
CAGSICEKYGLEECTCADKELCHVCCMKKMDPSTCASTGSVQWSRHFSGR
TITLQPGSPCNDFRGYCDVFMRCRLVDADGPLG
3D structure
PDB6be6 Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10.
ChainC
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.81: ADAM10 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H383 H387 H393 H167 H171 H177
BS02 CA C I459 C460 N462 M464 E469 D472 I243 C244 N246 M248 E253 D256
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6be6, PDBe:6be6, PDBj:6be6
PDBsum6be6
PubMed29224781
UniProtO14672|ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein 10 (Gene Name=ADAM10)

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