Structure of PDB 6bbn Chain C

Receptor sequence

>6bbnC (length=436) Species: 9913 (Bos taurus)

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTDDSFNTFFS
ETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYA
RGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLM
ERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMV
DNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTE
FQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVK
CDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVG
INYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAF
VHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSV

3D structure

• PDB: 6bbn Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.
• Chain: C
• Resolution: 3.514 Å

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GTP	C	G10 Q11 A12 Q15 I16 A99 A100 N101 G143 T145 V177 N206 Y224 N228	G10 Q11 A12 Q15 I16 A95 A96 N97 G139 T141 V173 N202 Y220 N224

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle
• GO:0007017 microtubule-based process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005856 cytoskeleton
• GO:0005874 microtubule
• GO:0015630 microtubule cytoskeleton

External links

• PDB: RCSB:6bbn, PDBe:6bbn, PDBj:6bbn
• PDBsum: 6bbn
• PubMed: 29980677
• UniProt: P81947|TBA1B_BOVIN Tubulin alpha-1B chain