Structure of PDB 6aw9 Chain C

Receptor sequence
>6aw9C (length=210) Species: 1026970 (Nannospalax galili) [Search protein sequence]
TKEQRILRYVQQHAKPDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDEVI
QEHNPSLVLELGAYCGYSAVRMARLLSPGARLLTMEKNPDYAAITQQMLN
FAGLQDKVTILIGASQDLIPQLKKYDVDTLDMVFLDHWKDRYLPDTILLE
ECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVD
GLEKAVYKGP
3D structure
PDB6aw9 Crystal structure of the catechol-o-methyl transferase (COMT) enzyme of the subterranean mole rat (Spalax) and the effect of L136M substitution
ChainC
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.6: catechol O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C D140 D168 N169 E198 D136 D164 N165 E194
BS02 SAH C M40 N41 V42 G66 Y68 S72 M89 E90 K91 Y95 S119 D140 H141 W142 M36 N37 V38 G62 Y64 S68 M85 E86 K87 Y91 S115 D136 H137 W138
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0016206 catechol O-methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006584 catecholamine metabolic process
GO:0032259 methylation
GO:0032502 developmental process
GO:0042417 dopamine metabolic process
GO:0042424 catecholamine catabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6aw9, PDBe:6aw9, PDBj:6aw9
PDBsum6aw9
PubMed
UniProtA0A452CSQ2

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