Structure of PDB 6aw8 Chain C

Receptor sequence
>6aw8C (length=212) Species: 1026970 (Nannospalax galili) [Search protein sequence]
DTKEQRILRYVQQHAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDE
VIQEHNPSLVLELGAYCGYSAVRMARLLSPGARLLTMEKNPDYAAITQQM
LNFAGLQDKVTILIGASQDLIPQLKKYDVDTLDLVFLDHWKDRYLPDTIL
LEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKV
VDGLEKAVYKGP
3D structure
PDB6aw8 Crystal structure of the catechol-o-methyl transferase (COMT) enzyme of the subterranean mole rat (Spalax) and the effect of L136M substitution
ChainC
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.6: catechol O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C D140 D168 N169 E198 D138 D166 N167 E196
BS02 SAH C M40 V42 G66 Y68 S72 E90 K91 Y95 S119 D140 H141 W142 M38 V40 G64 Y66 S70 E88 K89 Y93 S117 D138 H139 W140
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0016206 catechol O-methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006584 catecholamine metabolic process
GO:0032259 methylation
GO:0032502 developmental process
GO:0042417 dopamine metabolic process
GO:0042424 catecholamine catabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6aw8, PDBe:6aw8, PDBj:6aw8
PDBsum6aw8
PubMed
UniProtA0A452CSQ0

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