BioLiP

>6aljC (length=492) Species: 9606 (Homo sapiens) [Search protein sequence]

PSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKAD
IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESL
NGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEP
IGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALI
KEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG
RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRI
FVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQ
SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEIL
RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNA
LNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS

Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

NAD

I183 I184 P185 W186 N187 K210 G243 G247 F261 G263 S264 V267 E286 Q367 K370 E417 F419

I157 I158 P159 W160 N161 K184 G217 G221 F235 G237 S238 V241 E260 Q341 K344 E391 F393

BS02

CW2

G142 F188 L191 M192 W195 E286 C319 C320 L477 N478 A479

G116 F162 L165 M166 W169 E260 C293 C294 L451 N452 A453

BindingDB: Ki=56nM

Molecular Function

GO:0001758

retinal dehydrogenase activity

GO:0004028

3-chloroallyl aldehyde dehydrogenase activity

GO:0004029

aldehyde dehydrogenase (NAD+) activity

GO:0016491

oxidoreductase activity

GO:0016620

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

GO:0016918

retinal binding

	Biological Process
GO:0001568	blood vessel development
GO:0001822	kidney development
GO:0001889	liver development
GO:0002138	retinoic acid biosynthetic process
GO:0003007	heart morphogenesis
GO:0006629	lipid metabolic process
GO:0006776	vitamin A metabolic process
GO:0007494	midgut development
GO:0008283	cell population proliferation
GO:0008284	positive regulation of cell population proliferation
GO:0008285	negative regulation of cell population proliferation
GO:0009855	determination of bilateral symmetry
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010628	positive regulation of gene expression
GO:0014032	neural crest cell development
GO:0016331	morphogenesis of embryonic epithelium
GO:0021915	neural tube development
GO:0021983	pituitary gland development
GO:0030182	neuron differentiation
GO:0030324	lung development
GO:0030326	embryonic limb morphogenesis
GO:0030900	forebrain development
GO:0030902	hindbrain development
GO:0031016	pancreas development
GO:0031076	embryonic camera-type eye development
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0033189	response to vitamin A
GO:0034097	response to cytokine
GO:0035115	embryonic forelimb morphogenesis
GO:0035799	ureter maturation
GO:0042572	retinol metabolic process
GO:0042573	retinoic acid metabolic process
GO:0042574	retinal metabolic process
GO:0042904	9-cis-retinoic acid biosynthetic process
GO:0043010	camera-type eye development
GO:0043065	positive regulation of apoptotic process
GO:0048384	retinoic acid receptor signaling pathway
GO:0048566	embryonic digestive tract development
GO:0048738	cardiac muscle tissue development
GO:0051289	protein homotetramerization
GO:0060324	face development
GO:0071300	cellular response to retinoic acid
GO:1905562	regulation of vascular endothelial cell proliferation

Biological Process

GO:0001568

blood vessel development

GO:0001822

kidney development

GO:0001889

liver development

GO:0002138

retinoic acid biosynthetic process

GO:0003007

heart morphogenesis

GO:0006629