Structure of PDB 6ajb Chain C

Receptor sequence
>6ajbC (length=407) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
TGVLVELDGDEMTRVIWKKIKETLIFPFVNVPIEYYDLSMENRDKTEDRV
TVEAAYAIKKHGVGVKCATITPDEARVKEFNLKKMWRSPNGTIRTILGGT
VFREPIICSNVPRLVTTWKKPVVIGRHAFGDQYSATDAVVKEPGTFEMRF
IPANGGEPKVYKVFDYKSGGVMMGMYNTDDSIRDFARSCFEFALARKWPL
YLSTKNTILKHYDGRFKDIFAEMYKALYETKFKTCGIFYEHRLIDDMVAH
CMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGKTVEVEA
AHGTVTRHYRDYQKGKETSTNPVASIFAWTRALAHRARVDNNNTLLEFTQ
RLEDVIIATIEAGAMTEDLAICIKGEKNVVRADYLNTDEFIDAVSQRLKV
AMQKSKV
3D structure
PDB6ajb Biochemical characterization of a novel Trypanosoma brucei glycosomal isocitrate dehydrogenase with dual coenzyme specificity (NADP+/NAD+)
ChainC
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD C A74 T75 T77 H308 G309 T310 V311 R313 N327 A68 T69 T71 H302 G303 T304 V305 R307 N321
BS02 CA C D274 D278 D268 D272
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006739 NADP metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0020015 glycosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ajb, PDBe:6ajb, PDBj:6ajb
PDBsum6ajb
PubMed
UniProtQ387G0

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