Structure of PDB 6ahd Chain C

Receptor sequence
>6ahdC (length=818) Species: 9606 (Homo sapiens) [Search protein sequence]
TVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRTEQ
ERGVGIKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGV
VLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAY
YKLRHIVDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAK
IYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFVEFILE
PLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFG
EFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLM
CHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQIC
TVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQ
IFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESG
EHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCF
AETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWD
LLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTR
EGPLCDELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATP
RLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFI
PAIDSFGFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQP
APHLAREFMIKTRRRKGL
3D structure
PDB6ahd Structures of the human pre-catalytic spliceosome and its precursor spliceosome.
ChainC
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP C L138 H139 G141 K142 T143 C144 P206 G207 K259 D261 R262 S311 S312 Q313 L27 H28 G30 K31 T32 C33 P81 G82 K134 D136 R137 S186 S187 Q188
BS02 MG C T143 D204 T32 D79
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0042220 response to cocaine
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0043231 intracellular membrane-bounded organelle
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ahd, PDBe:6ahd, PDBj:6ahd
PDBsum6ahd
PubMed30315277
UniProtQ15029|U5S1_HUMAN 116 kDa U5 small nuclear ribonucleoprotein component (Gene Name=EFTUD2)

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