Structure of PDB 6ah5 Chain C

Receptor sequence
>6ah5C (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]
FFTYETPKVIVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAI
ESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGF
CPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTE
VDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFH
PDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQC
IPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFD
VLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAK
KFEEVNE
3D structure
PDB6ah5 Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP.
ChainC
Resolution3.819 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC C H45 E46 H39 E40
BS02 ATP C K63 K65 T172 F174 M200 I215 K57 K59 T166 F168 M194 I209 BindingDB: EC50=340nM
BS03 ATP C S275 N279 R281 K299 S269 N273 R275 K293 BindingDB: EC50=340nM
Gene Ontology
Molecular Function
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellularly ATP-gated monoatomic cation channel activity
GO:0005216 monoatomic ion channel activity
GO:0005524 ATP binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0033198 response to ATP
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6ah5, PDBe:6ah5, PDBj:6ah5
PDBsum6ah5
PubMed31232692
UniProtP56373|P2RX3_HUMAN P2X purinoceptor 3 (Gene Name=P2RX3)

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