Structure of PDB 6a3a Chain C

Receptor sequence
>6a3aC (length=996) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
GSMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAW
QKADQILQFSTNPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMI
ISMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSS
VNVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCF
QVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDT
RAITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLK
ATYANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLI
QLSKIEERELFKTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENM
VRPEEIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSWHNIN
TLSWAIGSISGTMSEDTEKRFVVTVIKDLLGLCEQKRGKDNKAVVASDIM
YVVGQYPRFLKAHWNFLRTVILKLFEFMHETHEGVQDMACDTFIKIVQKC
KYHFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACGIIISEER
SVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANIIKTN
VAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKV
RGLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDA
RDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINKDFTEYPEHR
VEFYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRDVEVNGLQ
IALDLVKNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQA
LLLMKLISLVYDNKISVPLYQEAEVPQGTSNQVYLSQYLANMLSNAFPHL
TSEQIASFLSALTKQCKDLVVFKGTLRDFLVQIKEVGGDPTDYLFA
3D structure
PDB6a3a Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor.
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C I532 L536 C539 K545 K548 I555 M556 F572 T575 K579 E586 I476 L480 C483 K489 K492 I499 M500 F516 T519 K523 E530
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6a3a, PDBe:6a3a, PDBj:6a3a
PDBsum6a3a
PubMed33883894
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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