Structure of PDB 5zqu Chain C

Receptor sequence
>5zquC (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
NDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIA
SFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQ
MDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQ
PGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP
3D structure
PDB5zqu Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor alpha (RXR alpha ).
ChainC
Resolution2.60039 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9HF C L436 F439 L175 F178 BindingDB: EC50=143nM
BS02 9HF C I268 A271 A272 Q275 W305 L326 F438 F439 I7 A10 A11 Q14 W44 L65 F177 F178 BindingDB: EC50=143nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zqu, PDBe:5zqu, PDBj:5zqu
PDBsum5zqu
PubMed30565665
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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