Structure of PDB 5zhx Chain C

Receptor sequence
>5zhxC (length=469) Species: 9606 (Homo sapiens) [Search protein sequence]
DAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTL
VKLLGIHCQNAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQ
IEHDKREMIFEVLAPLAENDAIKLQLVEAGLVECLLEIVQQKVDSDKEDD
ITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIPSNNHQLQLA
GALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAALSAL
RNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAE
AAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIKT
IVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLV
QILHRLLADERSAPEIKYNSMVLICALMGSECLHKEVQDLAFLDVVSKLR
SHENKSVAQQASLTEQRLT
3D structure
PDB5zhx GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism.
ChainC
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAR C L136 M152 L50 M66
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0043547 positive regulation of GTPase activity

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Molecular Function
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Biological Process
External links
PDB RCSB:5zhx, PDBe:5zhx, PDBj:5zhx
PDBsum5zhx
PubMed30190425
UniProtP52306|GDS1_HUMAN Rap1 GTPase-GDP dissociation stimulator 1 (Gene Name=RAP1GDS1)

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