Structure of PDB 5z12 Chain C

Receptor sequence
>5z12C (length=203) Species: 9606 (Homo sapiens) [Search protein sequence]
ERILEAELAVEPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLR
AGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTE
LVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEA
YCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLM
EML
3D structure
PDB5z12 Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR
ChainC
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C V280 Q297 R302 F450 E453 V28 Q45 R50 F198 E201
BS02 9CR C I268 Q275 F313 R316 L326 A327 V342 C432 L436 I16 Q23 F61 R64 L74 A75 V90 C180 L184 BindingDB: EC50=100nM,Ki=583nM,IC50=32nM,Kd=240nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5z12, PDBe:5z12, PDBj:5z12
PDBsum5z12
PubMed29934308
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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