Structure of PDB 5yxl Chain C

Receptor sequence
>5yxlC (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
TPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHV
QVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNSDLLEERI
RNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDRE
AVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLF
TPLLCEIWDV
3D structure
PDB5yxl A ligand M binding to FXR
ChainC
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C V56 K60 H70 L221 V54 K58 H68 L203
BS02 NIW C L44 F86 M122 F200 H203 H204 M207 W226 L42 F84 M113 F191 H194 H195 M198 W208
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5yxl, PDBe:5yxl, PDBj:5yxl
PDBsum5yxl
PubMed
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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