Structure of PDB 5yt3 Chain C

Receptor sequence
>5yt3C (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
LELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKP
SGLVMARKLIHAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICME
HMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPS
NILVNSRGEIKLCDFGSYMSPERLYSVQSDIWSMGLSLVEMAVGRYPIPP
PDAKELELMFGCPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIK
NPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN
3D structure
PDB5yt3 Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 S218D and S222D mutant
ChainC
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D190 K192 N195 D208
Catalytic site (residue number reindexed from 1) D146 K148 N151 D164
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP C L74 G75 G77 V82 A95 K97 E144 M146 S150 Q153 D190 K192 S194 N195 L197 D208 L35 G36 G38 V43 A56 K58 E100 M102 S106 Q109 D146 K148 S150 N151 L153 D164
BS02 MG C N195 D208 N151 D164
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5yt3, PDBe:5yt3, PDBj:5yt3
PDBsum5yt3
PubMed
UniProtQ02750|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (Gene Name=MAP2K1)

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