Structure of PDB 5yp4 Chain C

Receptor sequence
>5yp4C (length=687) Species: 128785 (Pseudoxanthomonas mexicana) [Search protein sequence]
AEKLTLEAITGSAPLSGPTLTKPQIAPDGSRVTFLRGKDRNRLDLWEYDI
ASGQTRLLVDSSVVLPLSGIVDYQWALLFPLGGELYFYAVRKLTGGFATD
PKISPKGGFVSFIRDRNLWAIDLASGKEVQLTRDGSDTIGNGVAEFVADE
EMDRHTGYWWAPDDAAIAFARIDETPVPVQKRYEVYPDRTEVVEQRYPAA
GDHNVRVQLGVIAPKTGARPRWIDLGKDPDIYLARVDWRDPQRLTFQRQS
RDQKKIELIETTLTNGTQRTLVTETSTTWVPLHNDLRFLKDGRFLWSSER
SGFEHLYVASEDGSTLTALTQGEWVVDSLLAIDEAAGLAYVSGTRDGATE
AHVYAVPLSGGEPRRLTQAPGMHAATFARNASVFVDSWSSDTTLPQIELF
KADGTKLATLLVNDVSDATHPYAKYRAAHQPTAYGTLTAADGTTPLHYSL
IKPAGFDPKKQYPVVVFVYGGPAAQTVTRAWPGRSDSFFNQYLAQQGYVV
FTLDNRGTPRRGAAFGGALYGKQGTVEVDDQLRGIEWLKSQAFVDPARIG
VYGWSNGGYMTLMLLAKHDEAYACGVAGAPVTDWALYDTHYTERYMDLPK
ANEAGYREASVFTHVDGIGAGKLLLIHGMADDNVLFTNSTKLMSELQKRG
TPFELMTYPGAKHGLRGSDLLHRYRLTEDFFARCLKP
3D structure
PDB5yp4 Crystal structures of a bacterial dipeptidyl peptidase IV reveal a novel substrate recognition mechanism distinct from that of mammalian orthologues.
ChainC
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y527 S613 N614 D689 H721
Catalytic site (residue number reindexed from 1) Y469 S555 N556 D631 H663
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LYS C E209 Y645 E151 Y587
BS02 PRO C Y527 S613 N614 Y645 Y649 Y469 S555 N556 Y587 Y591
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5yp4, PDBe:5yp4, PDBj:5yp4
PDBsum5yp4
PubMed29426867
UniProtQ6F3I7|DAP4_PSEMX Dipeptidyl aminopeptidase 4 (Gene Name=dap4)

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