Structure of PDB 5yew Chain C

Receptor sequence
>5yewC (length=389) Species: 9606 (Homo sapiens) [Search protein sequence]
SPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLV
EMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGI
GHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAG
CLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVLV
ANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQ
HMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKALAEGFHARL
QEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAED
LPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLPS
3D structure
PDB5yew Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion
ChainC
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP C S85 G87 K88 S89 S90 S103 G104 N237 R238 D240 S284 K286 S80 G82 K83 S84 S85 S98 G99 N232 R233 D235 S279 K281
BS02 BEF C T84 K88 H107 G181 T79 K83 H102 G176
BS03 K C T84 S85 G104 G106 H107 I108 T79 S80 G99 G101 H102 I103
BS04 MG C S89 T109 S84 T104
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0008053 mitochondrial fusion
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5yew, PDBe:5yew, PDBj:5yew
PDBsum5yew
PubMed29483649
UniProtQ8IWA4|MFN1_HUMAN Mitofusin-1 (Gene Name=MFN1)

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