Structure of PDB 5y4p Chain C

Receptor sequence
>5y4pC (length=273) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
GWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMAL
DGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHG
TVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPD
NTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRE
TGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDL
KYYDSEMHKASFALPRFARHINN
3D structure
PDB5y4p Discovering a hidden allosteric binding site by combining molecular simulations and X-ray crystallography
ChainC
Resolution2.16 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M C Q40 L59 Q64 G95 D98 D118 I119 D168 T169 Q31 L50 Q55 G86 D89 D109 I110 D159 T160
BS02 8QO C E14 M24 W53 I63 D69 Y73 T236 Y237 P238 E5 M15 W44 I54 D60 Y64 T215 Y216 P217
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5y4p, PDBe:5y4p, PDBj:5y4p
PDBsum5y4p
PubMed37521650
UniProtQ4DA73

[Back to BioLiP]