Structure of PDB 5xii Chain C

Receptor sequence
>5xiiC (length=479) Species: 508771 (Toxoplasma gondii ME49) [Search protein sequence]
MVTAKKDENFSEWYTQAIVRSEMIEYYDISGCYIMRPWAFHIWEKVQRFF
DDEIKKMGVENSYFPMFVSRHKLEKGFSPEVAWVTHYGDSPLPEKIAIRP
TSETIMYPAYAKWIRSHRDLPLKLNQWCSVVRWEFKQPTPFLRTREFLWQ
EGHTAHATEEEAWELVLDILELYRRWYEECLAVPVIKGEKSEGEKFAGGK
KTTTVEAFIPENGRGIQAATSHLLGTNFAKMFEIEFEDEEGHKRLVHQTS
WGCTTRSLGVMIMTHGDDKGLVIPPRVASVQVVIIPILFKDENTGEILGK
CRELKTMLEKADIRVRIDDRSNYTPGWKYNHWEVKGVPLRLELGPKDLAK
GTARVVRRDTGEAYQISWADLAPKLLELMEGIQRSLFEKAKARLHEGIEK
ISTFDEVMPALNRKHLVLAPWCEDPESEEQIKKETQKLSEIGAMKTLCIP
FDQPPMPEGTKCFYTGKPAKRWTLWGRSY
3D structure
PDB5xii Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
ChainC
Resolution2.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.15: proline--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP C R470 E472 R481 T482 F485 Q555 T558 T592 R594 R132 E134 R143 T144 F147 Q217 T220 T254 R256
BS02 86X C F415 V419 P438 T439 E441 R470 W487 F534 H560 F77 V81 P100 T101 E103 R132 W149 F196 H222 MOAD: ic50=72nM
PDBbind-CN: -logKd/Ki=7.12,IC50=75nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004827 proline-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006433 prolyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xii, PDBe:5xii, PDBj:5xii
PDBsum5xii
PubMed28867614
UniProtS8G8I1

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