Structure of PDB 5xf4 Chain C

Receptor sequence
>5xf4C (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
AKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEIL
ELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQA
VLLPKK
3D structure
PDB5xf4 Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
ChainC
Resolution2.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C A14 K15 R17 R20 R29 R32 R42 R77 A1 K2 R4 R7 R16 R19 R29 R64
BS02 dna C R29 R35 R42 G44 A45 K75 T76 R77 R16 R22 R29 G31 A32 K62 T63 R64
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xf4, PDBe:5xf4, PDBj:5xf4
PDBsum5xf4
PubMed29146919
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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