Structure of PDB 5xet Chain C

Receptor sequence
>5xetC (length=505) Species: 419947 (Mycobacterium tuberculosis H37Ra) [Search protein sequence]
KPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDRYDVRFLTGTDEH
GLKVAQAAAAAGVPTAALARRNSDVFQRMQEALNISFDRFIRTTDADHHE
ASKELWRRMSAAGDIYLDNYSGWYSVRDERFFVESETQLVDGTRLTVETG
TPVTWTEEQTYFFRLSAYTDKLLAHYHANPDFIAPETRRNEVISFVSGGL
DDLSISRTSFDWGVQVPEHPDHVMYVWVDALTNYLTGAGFPDTDSELFRR
YWPADLHMIGKDIIRFHAVYWPAFLMSAGIELPRRIFAHGFLHNRKMSKS
VGNIVDPVALAEALGVDQVRYFLLREVPFGQDGSYSDEAIVTRINTDLAN
ELGNLAQRSLSMVAKNLDGRVPNPGEFADADAALLATADGLLERVRGHFD
AQAMHLALEAIWLMLGDANKYFSVQQPWVLRKSESEADQARFRTTLYVTC
EVVRIAALLIQPVMPESAGKILDLLGQAPNQRSFAAVGVRLTPGTALPPP
TGVFP
3D structure
PDB5xet Structural characterization of free-state and product-stateMycobacterium tuberculosismethionyl-tRNA synthetase reveals an induced-fit ligand-recognition mechanism.
ChainC
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) I10 D49 W228 I264 K299 K302
Catalytic site (residue number reindexed from 1) I9 D48 W227 I263 K296 K299
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ME8 C A9 I10 A11 Y12 H18 G20 E24 D49 W228 A231 Y235 G261 D263 I264 H290 F292 A8 I9 A10 Y11 H17 G19 E23 D48 W227 A230 Y234 G260 D262 I263 H289 F291
BS02 MG C S301 V308 S298 V305
BS03 MG C Y23 V330 F332 Y22 V327 F329
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:5xet, PDBe:5xet, PDBj:5xet
PDBsum5xet
PubMed30002848
UniProtA5U150

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