Structure of PDB 5wzz Chain C

Receptor sequence
>5wzzC (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLD
AVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLV
LEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRS
IHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB5wzz The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation
ChainC
Resolution2.103 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C L158 Q159 G160 D162 I163 V164 F165 L166 T168 D177 W178 V179 L66 Q67 G68 D70 I71 V72 F73 L74 T76 D85 W86 V87
BS02 ZN C C98 C105 H117 C121 C6 C13 H25 C29
BS03 ZN C C128 C135 H147 H152 C36 C43 H55 H60
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:5wzz, PDBe:5wzz, PDBj:5wzz
PDBsum5wzz
PubMed28546513
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

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