Structure of PDB 5wrj Chain C

Receptor sequence
>5wrjC (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
AYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQM
WSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFA
LKSLTYLSRLFPNAKFLLMVRDGRASVHSMISRKVTIAGFDLNSYRDCLT
KWNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNH
SVLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQD
MAVIAPMLAKLGYDPYANPPNYG
3D structure
PDB5wrj Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1.
ChainC
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.2.20: protein-tyrosine sulfotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C E100 R106 P161 T199 I200 A201 E37 R43 P98 T136 I137 A138
BS02 A3P C R79 G81 T82 T83 L84 R184 S192 R196 Y239 H268 S286 Q289 V290 P293 N295 A298 R16 G18 T19 T20 L21 R121 S129 R133 Y176 H205 S223 Q226 V227 P230 N232 A235
BS03 MG C D90 H92 P93 I95 G276 D27 H29 P30 I32 G213
Gene Ontology
Molecular Function
GO:0008476 protein-tyrosine sulfotransferase activity
Biological Process
GO:0006478 peptidyl-tyrosine sulfation

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Molecular Function
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Biological Process
External links
PDB RCSB:5wrj, PDBe:5wrj, PDBj:5wrj
PDBsum5wrj
PubMed28821720
UniProtO60507|TPST1_HUMAN Protein-tyrosine sulfotransferase 1 (Gene Name=TPST1)

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