Structure of PDB 5wch Chain C

Receptor sequence
>5wchC (length=342) Species: 9606 (Homo sapiens) [Search protein sequence]
GFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGTEDRAAYNIGVL
RHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLV
DSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDI
RNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLA
IQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGSTKYRLV
GVLVHSGQASGGHYYSYIIQRRWYKFDDGDVTECKMDDDEEMKNQCFGGE
YMGEVFDHKRMSYRRQKRWWNAYILFYERMDTQDDELIRYIS
3D structure
PDB5wch Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C1727 H1729 C1771 C1774 C133 H135 C177 C180
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5wch, PDBe:5wch, PDBj:5wch
PDBsum5wch
PubMed30914461
UniProtQ93008|USP9X_HUMAN Ubiquitin carboxyl-terminal hydrolase 9X (Gene Name=USP9X)

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