Structure of PDB 5w9c Chain C

Receptor sequence
>5w9cC (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTADQMVSALLDAEPPILYSERPFSEASMMGLLTNLADRELVHMINWAK
RVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDR
NQGGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKSL
EEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN
KGMEHLYSMKSKNVVPSYDLLLEMLDAH
3D structure
PDB5w9c Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.
ChainC
Resolution1.802 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OHT C M343 L346 A350 D351 E353 M421 L525 V533 M31 L34 A38 D39 E41 M105 L206 V214 BindingDB: IC50=0.790000nM,EC50=10.3nM,Ki=5.7nM
External links
PDB RCSB:5w9c, PDBe:5w9c, PDBj:5w9c
PDBsum5w9c
PubMed29739819
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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