Structure of PDB 5w8u Chain C

Receptor sequence
>5w8uC (length=319) Species: 1235996 (Human betacoronavirus 2c EMC/2012) [Search protein sequence]
LTIEVLVTVDGVNFRTVVLNNKNTYRSQLGCVFFNGADISDTIPDEKQNG
HSLYLADNLTADETKALKELYGPVDPTFLHRFYSLKAAVHGWKMVVCDKV
RSLKLSDNNCYLNAVIMTLDLLKDIKFVIPALQHAFMKHKGGDSTDFIAL
IMAYGNCTFGAPDDASRLLHTVLAKAELCCSARMVWREWCNVCGIKDVVL
QGLKACCYVGVQTVEDLRARMTYVCQCGGERHRQLVEHTTPWLLLSGTPN
EKLVTTSTAPDFVAFNVFQGIETAVGHYVHARLKGGLILKFDSGTVSKTS
DWKCKVTDVLFPGQKYSSD
3D structure
PDB5w8u Structurally Guided Removal of DeISGylase Biochemical Activity from Papain-Like Protease Originating from Middle East Respiratory Syndrome Coronavirus.
ChainC
Resolution2.411 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C32 H81 C31 H80
BS02 ZN C C191 C194 C226 C228 C190 C193 C225 C227
BS03 AYE C N109 C111 H278 N108 C110 H277
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5w8u, PDBe:5w8u, PDBj:5w8u
PDBsum5w8u
PubMed28931677
UniProtM4STU1

[Back to BioLiP]