Structure of PDB 5w7c Chain C

Receptor sequence
>5w7cC (length=420) Species: 9606 (Homo sapiens) [Search protein sequence]
GSDICSLPVLAKICQKIKLAMEQSVPFKDVDSDKYSVFPTLRGYHWRGRD
CNDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKDGVPYEKKFCEGSQPR
GIILLGDAAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQLSGAT
GFLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLS
RNKVLDYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNS
HLPNGSHVILYGLPDGTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQ
VSPCHGWMSSNKTLRTLTSERAEQLSNTLKKIAASEKFTNFNLFYMDFAF
HEIIQEWQKRGGQPWQLIEPVDGFHPNEVALLLLADHFWKKVQLQWPQIL
GKENPFNPQIKQVFGDQGGH
3D structure
PDB5w7c Crystal structure of the mammalian lipopolysaccharide detoxifier.
ChainC
Resolution2.23 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.1.77: acyloxyacyl hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C D184 D186 D188 Y190 D205 D208 D29 D31 D33 Y35 D50 D53
BS02 CA C D186 D188 D205 N207 D210 V213 D31 D33 D50 N52 D55 V58
BS03 CA C D223 D227 N229 N231 I233 E245 D68 D72 N74 N76 I78 E90
Gene Ontology
Molecular Function
GO:0016788 hydrolase activity, acting on ester bonds
GO:0050528 acyloxyacyl hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5w7c, PDBe:5w7c, PDBj:5w7c
PDBsum5w7c
PubMed29343645
UniProtP28039|AOAH_HUMAN Acyloxyacyl hydrolase (Gene Name=AOAH)

[Back to BioLiP]