Structure of PDB 5w5h Chain C

Receptor sequence

>5w5hC (length=446) Species: 9606 (Homo sapiens) [Search protein sequence]

QVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNLL
AYVKHLKGQNEEALKSLKEAENLMQEANVRSLVTWGNFAWMYYHMGRLAE
AQTYLDKVENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKAC
FEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLN
PDNGYIKVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYAAKFYRR
KGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMIQIKEREKLDKMIR
SAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHRKAEENFQKLLCMKPVV
EETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIKIEQASLTRDKSINSLK
KLVLRKLRRKALDLESLSLLGFVYKLEGNMNEALEYYERALRLAAD

3D structure

PDB

5w5h Structural insights into IFIT1 dimerization and conformational changes associated with mRNA binding

Chain

Resolution

2.79 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	C	R38 Q42 T48 W147 L150 K151 G154 Y157 I183 R187 F191 L193 A194 N216 Y218 Y252 Y256 K259 H289 Q290 L293 K336 F339 V341 D345 D379	R30 Q34 T40 W134 L137 K138 G141 Y144 I170 R174 F178 L180 A181 N203 Y205 Y239 Y243 K246 H276 Q277 L280 K313 F316 V318 D322 D356

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0005515	protein binding

	Biological Process
GO:0009615	response to virus
GO:0019060	intracellular transport of viral protein in host cell
GO:0032091	negative regulation of protein binding
GO:0045070	positive regulation of viral genome replication
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response
GO:0051097	negative regulation of helicase activity
GO:0051607	defense response to virus
GO:0051707	response to other organism
GO:0071357	cellular response to type I interferon
GO:0071360	cellular response to exogenous dsRNA
GO:0140374	antiviral innate immune response

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043657	host cell

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5w5h, PDBe:5w5h, PDBj:5w5h
PDBsum	5w5h
PubMed
UniProt	P09914\|IFIT1_HUMAN Interferon-induced protein with tetratricopeptide repeats 1 (Gene Name=IFIT1)

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