Structure of PDB 5w4t Chain C

Receptor sequence

>5w4tC (length=316) Species: 7955 (Danio rerio)

MNQPPRFQNYFFQSYLLVYEDTPVGTSITQLQAVDPDGEPLIFGVVGEEA
MRYFAVQGTTGVVWLRQPLDREAKSEMQVEFTVSDSQGVVKDTVNIQIGD
VNDNAPSFYNQPYAIQIPENTPVGTSVFMVNATDPDQGVGGSVLFSFQPP
SQFFSIDGARGIVTVTRALDYETTIAYQLTVNATDQDKRRPLSSLANLAI
TITDIQDMDPIFTNLPYSTNIMEDAPPGYEVRKIRAIDQDLGRPRGIGYT
IISGNTNSMFALDYISGSLTVSGQLDRENPLYSSGFIITVKATELNDDRT
PSSATVTTTFTILLID

3D structure

• PDB: 5w4t Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
• Chain: C
• Resolution: 2.65 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	C	N1 Q2 D34 D36 E38 D84	N2 Q3 D35 D37 E39 D85
BS02	CA	C	E19 D69 E71 D102	E20 D70 E72 D103
BS03	CA	C	E19 E71 D99 V100 D102 D135	E20 E72 D100 V101 D103 D136
BS04	CA	C	N101 N103 D133 D135 G139 D184	N102 N104 D134 D136 G140 D185
BS05	CA	C	E118 E171 D203 I204 D206 D239	E119 E172 D204 I205 D207 D240
BS06	CA	C	E118 D169 E171 D206	E119 D170 E172 D207
BS07	CA	C	Q205 M207 D237 D239 E293	Q206 M208 D238 D240 E294

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5w4t, PDBe:5w4t, PDBj:5w4t
• PDBsum: 5w4t
• PubMed: 30033219
• UniProt: F1R7G8