Structure of PDB 5w3v Chain C

Receptor sequence
>5w3vC (length=184) Species: 9545 (Macaca nemestrina) [Search protein sequence]
ALLTAKTFSLQFNNKRRVNKPYYPRKALLCYQLTPQNGSTPTRGHLINKK
EDHAEIRFINEIKSMGLDETQDYQVTCYLTWSPCPSCAGELVDFIKAHRH
LNLRIFASRLYYHWHPNYQEGLLLLCGSQVPVEVMGLPEFTDCWENFVDH
KEPPSFNPSEKLKELDKNSQAIKRRLERIKSRSV
3D structure
PDB5w3v APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA.
ChainC
Resolution2.243 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C K16 R17 N20 Y23 H114 W115 R175 R176 K15 R16 N19 Y22 H113 W114 R174 R175
BS02 rna C V19 Y23 Y24 P25 R26 K51 W82 Y112 Y113 W115 V18 Y22 Y23 P24 R25 K50 W81 Y111 Y112 W114
BS03 ZN C H54 C85 C88 H53 C84 C87
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0016554 cytidine to uridine editing
GO:0045087 innate immune response
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0051607 defense response to virus
GO:0070383 DNA cytosine deamination
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:5w3v, PDBe:5w3v, PDBj:5w3v
PDBsum5w3v
PubMed29044109
UniProtA0A1B2AH37

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