Structure of PDB 5w0n Chain C

Receptor sequence
>5w0nC (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQD
FPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLETAEGLDCVRTIEELARV
LRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSA
YSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNP
PVIPVLQEIYKGEKKPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQ
LWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNH
NLGAGLSRKMTNFIMKAFINGRRVFGIPVSKMEYFFDPDVLTEGELAPND
3D structure
PDB5w0n Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
ChainC
Resolution2.497 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.52: RNA uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C D1058 D1060 D72 D74
BS02 2KH C F1045 G1046 S1047 S1057 D1058 D1060 N1130 K1152 S1170 Y1171 L1288 F59 G60 S61 S71 D72 D74 N144 K166 S184 Y185 L302
BS03 UPU C F1045 D1060 I1099 V1104 I1106 D1119 N1124 S1164 F59 D74 I113 V118 I120 D133 N138 S178
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5w0n, PDBe:5w0n, PDBj:5w0n
PDBsum5w0n
PubMed28671666
UniProtQ5VYS8|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)

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