Structure of PDB 5vrn Chain C

Receptor sequence
>5vrnC (length=261) Species: 83331 (Mycobacterium tuberculosis CDC1551) [Search protein sequence]
GLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITD
RLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQPF
FDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAY
NWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALG
EEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDII
YADGGAHTQLL
3D structure
PDB5vrn Discovery of a cofactor-independent inhibitor ofMycobacterium tuberculosisInhA.
ChainC
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y158 K165
Catalytic site (residue number reindexed from 1) Y150 K157
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9JM C G14 I16 S20 I21 F41 D64 V65 S94 I95 G96 I122 M147 D148 F149 Y158 M161 K165 P193 I194 T196 M199 L218 G12 I14 S18 I19 F39 D62 V63 S92 I93 G94 I114 M139 D140 F141 Y150 M153 K157 P185 I186 T188 M191 L210
Gene Ontology
Molecular Function
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0005504 fatty acid binding
GO:0016491 oxidoreductase activity
GO:0050343 trans-2-enoyl-CoA reductase (NADH) activity
GO:0070403 NAD+ binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0030497 fatty acid elongation
GO:0046677 response to antibiotic
GO:0071768 mycolic acid biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Cellular Component
External links
PDB RCSB:5vrn, PDBe:5vrn, PDBj:5vrn
PDBsum5vrn
PubMed30456352
UniProtP9WGR1|INHA_MYCTU Enoyl-[acyl-carrier-protein] reductase [NADH] (Gene Name=inhA)

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