Structure of PDB 5vr8 Chain C

Receptor sequence
>5vr8C (length=462) Species: 9606 (Homo sapiens) [Search protein sequence]
HMFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPT
LPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMG
KGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTK
PNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVY
EHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVE
EVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARY
WQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESS
SIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHEDDQVSRLVTISKDPYE
ACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQ
TIGFQIETIGKK
3D structure
PDB5vr8 The entropic force generated by intrinsically disordered segments tunes protein function.
ChainC
Resolution1.999 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T131 E165 K220 N224 C276 D280
Catalytic site (residue number reindexed from 1) T132 E166 K221 N225 C277 D281
Enzyme Commision number 1.1.1.22: UDP-glucose 6-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C I10 G13 Y14 D36 V37 R41 V89 N90 C112 R346 I11 G14 Y15 D37 V38 R42 V90 N91 C113 R347
BS02 UDX C F162 L163 A164 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442 F163 L164 A165 K221 I232 F266 K268 S270 F273 G274 C277 F278 F339 K340 R439
Gene Ontology
Molecular Function
GO:0003979 UDP-glucose 6-dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
GO:0051287 NAD binding
Biological Process
GO:0001702 gastrulation with mouth forming second
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006065 UDP-glucuronate biosynthetic process
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0034214 protein hexamerization
GO:0048666 neuron development
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vr8, PDBe:5vr8, PDBj:5vr8
PDBsum5vr8
PubMed30420606
UniProtO60701|UGDH_HUMAN UDP-glucose 6-dehydrogenase (Gene Name=UGDH)

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