Structure of PDB 5vmp Chain C

Receptor sequence
>5vmpC (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
ARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDD
IDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRY
FEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKE
SGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPP
EHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQE
AGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKISM
DVFVRKFQPERYKLWKAGKTVIDHTLPTPEAAEFL
3D structure
PDB5vmp Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
ChainC
Resolution2.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1) G157 Y164 H175 E177 H263 S275
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69: [histone H3]-trimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C234 H240 C306 C221 H227 C293
BS02 9FJ C Q73 Y132 F185 H188 K206 W208 H240 K241 H276 Q62 Y119 F172 H175 K193 W195 H227 K228 H263
External links
PDB RCSB:5vmp, PDBe:5vmp, PDBj:5vmp
PDBsum5vmp
PubMed28835804
UniProtO75164|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)

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