Structure of PDB 5vie Chain C

Receptor sequence

>5vieC (length=667) Species: 9606 (Homo sapiens) [Search protein sequence]

EEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPT
FADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSG
NIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIV
ADQLELPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHP
KDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPD
DGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGA
RNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKL
AYMPHTFFIGDHANMFPHLKKKAVIDFIYDNRIVLNGIDLKAFLDSLPDV
KIVNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAAT
GEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVP
NSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLAD
VCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELI
AKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERL
YLQMWEHYAANKPDHMI

3D structure

PDB

5vie Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	L371 K375 M398	L38 K42 M65
BS02	peptide	C	H496 H498 H499 N557 H558 P559 Y632 T633 K634 V895 P897	H160 H162 H163 N221 H222 P223 Y296 T297 K298 V536 P538
BS03	UDP	C	K842 V895 A896 K898 H901 H920 T921 T922 D925	K483 V536 A537 K539 H542 H561 T562 T563 D566	BindingDB: IC50=1800nM
BS04	9CD	C	H498 M501 P559 T560 L653 P656 F694 Y841 C917 H920	H162 M165 P223 T224 L317 P320 F358 Y482 C558 H561

External links

PDB	RCSB:5vie, PDBe:5vie, PDBj:5vie
PDBsum	5vie
PubMed	29058723
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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