Structure of PDB 5vem Chain C

Receptor sequence
>5vemC (length=374) Species: 9606 (Homo sapiens) [Search protein sequence]
QKVLLVSFDGFRWDYLYKVPTPHFHYIMKYGVHVKQVTNVFITKTYPNHY
TLVTGLFAENHGIVANDMFDPIRNKSFSLDHMNIYDSKFWEEATPIWITN
QRAGHTSGAAMWPGTDVKIHKRFPTHYMPYNESVSFEDRVAKIIEWFTSK
EPINLGLLYWEDPDDMGHHLGPDSPLMGPVISDIDKKLGYLIQMLKKAKL
WNTLNLIITSDHGMTQCSEERLIELDQYLDKDHYTLIDQSPVAAILPKEG
KFDEVYEALTHAHPNLTVYKKEDVPERWHYKYNSRIQPIIAVADEGWHIL
QNKSDDFLLGNHGYDNALADMHPIFLAHGPAFRKNFSKEAMNSTDLYPLL
CHLLNITAMPHNGSFWNVQDLLNS
3D structure
PDB5vem A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP5.
ChainC
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C D36 T72 D238 H239 D9 T45 D211 H212
BS02 ZN C D191 H195 H339 D164 H168 H312
BS03 ZN C D192 H196 D165 H169
Gene Ontology
Molecular Function
GO:0000210 NAD+ diphosphatase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0007154 cell communication
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vem, PDBe:5vem, PDBj:5vem
PDBsum5vem
PubMed28898552
UniProtQ9UJA9|ENPP5_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (Gene Name=ENPP5)

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