Structure of PDB 5v84 Chain C

Receptor sequence
>5v84C (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
DDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEK
KLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMM
KH
3D structure
PDB5v84 GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2).
ChainC
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 96V C M503 H532 M67 H96 BindingDB: IC50=190nM
BS02 96V C P458 F459 V463 Y467 N514 Y520 P22 F23 V27 Y31 N78 Y84 BindingDB: IC50=190nM
Gene Ontology
Biological Process
GO:0006338 chromatin remodeling
Cellular Component
GO:0090537 CERF complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5v84, PDBe:5v84, PDBj:5v84
PDBsum5v84
PubMed28740608
UniProtQ9BXF3|CECR2_HUMAN Chromatin remodeling regulator CECR2 (Gene Name=CECR2)

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