Structure of PDB 5v6y Chain C

Receptor sequence

>5v6yC (length=549) Species: 9606,83333 [Search protein sequence]

EEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAA
TGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGK
LIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQ
EPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNK
HMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKG
QPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAV
ALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAAS
GRQTVDEALKDAQTNAAAEFTTACQEANYGALLRELCLTQFQVDMEAVGE
TLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRS
CPILGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAA
GTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNV

3D structure

PDB

5v6y Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	C	A340 Y343 A344 R356 N369 L2034 T2037 D2070 G2071 W2072 F2092 Q2093 D2094 F2095 H2114 A2116 S2117 R2119 W2121 T2122	A336 Y339 A340 R352 N365 L454 T457 D490 G491 W492 F512 Q513 D514 F515 H534 A536 S537 R539 W541 T542
BS02	GLC	C	K17 E155 Y157 W232	K13 E151 Y153 W228
BS03	GLC	C	W64 D67 R68 E155 P156 Y157 W342	W60 D63 R64 E151 P152 Y153 W338

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0015026	coreceptor activity
GO:0015144	carbohydrate transmembrane transporter activity

	Biological Process
GO:0006886	intracellular protein transport
GO:0007186	G protein-coupled receptor signaling pathway
GO:0008277	regulation of G protein-coupled receptor signaling pathway
GO:0008643	carbohydrate transport
GO:0055085	transmembrane transport

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5v6y, PDBe:5v6y, PDBj:5v6y
PDBsum	5v6y
PubMed	29363552
UniProt	O60894\|RAMP1_HUMAN Receptor activity-modifying protein 1 (Gene Name=RAMP1); P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q16602\|CALRL_HUMAN Calcitonin gene-related peptide type 1 receptor (Gene Name=CALCRL)

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